Disorders of Renal Tubular Phosphate Transport

Genetic disorders of renal phosphate transport.

Renal tubular effects of chronic phosphate depletion.

The effects of chronic phosphate depletion on renal tubular function were evaluated by micropuncture and free water clearance studies in the dog. Proximal tubular punctures demonstrated that chronic hypophosphatemia led to a reduction in ratio of tubular fluid to plasma inulin in late superficial tubular from 1.59+/-0.08 in control animals to 1.29+/-0.06 in phosphate-depleted dogs, with proport...

Approach to renal tubular disorders.

The renal tubule plays an important role in fluid and electrolyte homeostasis. Renal tubular disorders may affect multiple ( e.g., Fanconi syndrome) or specific (e.g., nephrogenic diabetes insipidus, renal glucosuria) tubular functions. Most conditions are primary and monogenic but occasionally are secondary to other disorders (focal segmental glomerulosclerosis, cystinosis, Lowe syndrome). Tub...

OSR1-sensitive renal tubular phosphate reabsorption.

BACKGROUND The oxidative stress-responsive kinase 1 (OSR1) participates in the WNK-(with no K) kinase dependent regulation of renal salt excretion and blood pressure. Little is known, however, about the role of OSR1 in the regulation of further renal transport systems. The present study analyzed the effect of OSR1 on NaPiIIa, the major renal tubular phosphate transporter. METHODS Immunohistoc...

Cellular phosphate in renal tubular acidosis.

In two infants with distal renal tubular acidosis phosphate depletion was observed in the extracellular and intracellular compartments of the erythrocytes. Treatment corrected this disturbance over a period of several months. Cell phosphate deficiency may contribute to the adverse effects of renal tubular acidosis on bone.